32 KJEMI 4 2025 Universitet og dato: UiT, Kjemisk institutt, 19. juni, 2024 Navn: Fredrik Garnås Rylandsholm Veiledere: Hovedveileder: Professor Johan Isaksson, Co-veiledere: Professor John Sigurd Mjøen Svendsen Opponenter: First opponent: Professor Christina Thiele, University of Darmstadt, Germany Second opponent: Professor Finn L. Aachmann, Department of Biotechnology and Food Science, NTNU, Norway Committee coordinator: Professor Annette Bayer, Department of Chemistry, UiT Tittel på prøveforelesning: Thermodynamics of binding and methods to measure them Tittel på avhandling: Structural characterisation and drug-lipid interaction by NMR spectroscopy Sammendrag: Since the discovery of antimicrobial agents and the extensive use in infection treatment and prevention, antimicrobial resistance (AMR) has become a rapidly increasing problem. The World health organisation (WHO) surveys a wide range of human pathogens, including several multi-resistant pathogens causing infections with high morbidity and mortality. Emphasising the urgency of new treatment strategies, is the fact that WHO estimates that by 2050, antibiotic resistance will surpass deaths due to cancer, with up to 10 million people dying each year. There is a sore need for new alternatives and strategies. One prominent alternative is antimicrobial peptides (AMPs). AMPs are an integral part of life, as hostdefence peptides, and are found in all domains of life. Bacteria have lower chance of developing resistance against AMPs, partially because of their diverse modes-of-action. This is therefore a promising strategy to prolong the potential usage of AMPs in future therapy. Since the discovery of AMPs, there has been extensive work revealing their modes-of-action and connections between structure and effect. As they are a diverse group of molecules, and their targets are even more complicated, there are still many things that are not yet fully understood. Expanding our knowledge regarding AMP-target interactions, future research can potentially resolve the emerging challenges in infection control and treatment, broadening the currently available treatment options.In this dissertation for the degree of philosophiae doctor, this work focuses on both refining methodological approaches and generating a new understanding about selected AMPs. Efforts towards developing a robust platform for further investigation of AMPs looking for complementary agents to antibiotics or adjuvating strategies to aid for more effective antibiotic treatment strategies have been initiated. For that purpose, finetuned instrumental approaches are crucial for driving our research further in this field and uncovering new knowledge. Disputaser ved UiT høst 2024 og hittil i 2025 Universitet og dato: UiT, Kjemisk institutt, 26. juni, 2024 Navn: Alexandra Kondratieva Veiledere: Hovedveileder: Professor Annette Bayer, Co-veiledere: Professor Hanna-Kirsti S. Leiros Opponenter: First opponent: Professor Dr. Jörg Rademan, Freie University, Germany Second opponent: Associate Professor Dr. Anders Vik, UiO Committee coordinator: Post doc. Torsha Moitra, Department of Chemistry, UiT Tittel på prøveforelesning: Fluorine in medicinal chemistry – synthesis and applications Tittel på avhandling: Exploring fluorination in MBL inhibitor design Sammendrag: Antimicrobial resistance (AMR) achieved through, among others, β-lactamase activity, remains an ongoing challenge for the treatment of infections caused by antibiotic-resistant pathogens. Metallo-β-lactamase (MBL)- expressing bacteria, resistant to most β-lactam antibiotics, are of growing clinical relevance with currently no approved treatment options available. The most common approaches to combating AMR include the modification of existing
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